The criteria for inclusion are (all must be met):
- Both players must have a career high ranking of No. 3 or better, and one of them must have reached No. 1.
- The players must have met several times in semi-finals or finals of a Grand Slam.
- They must have at least a total of 12 career meetings in main tour matches.
Active rivalries are highlighted.
| Rivalry | Meetings | Period | Grand Slam Matches | Grand Slam | All Matches | Grand Slam Finals | All Finals |
|---|---|---|---|---|---|---|---|
| Lendl–McEnroe | 36 | 1980–1992 | 10 | 7–3 | 21–15 | 3 | 20 |
| Connors–Lendl | 35 | 1979–1992 | 7 | 3–4 | 13–22 | 2 | 7 |
| Becker–Edberg | 35 | 1984–1996 | 4 | 1–3 | 25–10 | 3 | 16 |
| Agassi–Sampras | 34 | 1989–2002 | 9 | 3–6 | 14–20 | 5 | 16 |
| Connors–McEnroe | 34 | 1977–1991 | 9 | 3–6 | 14–20 | 2 | 15 |
| Djokovic–Nadal | 30 | 2006– | 8 | 3–5 | 14–16 | 4 | 12 |
| Federer–Nadal | 28 | 2004– | 10 | 2–8 | 10–18 | 8 | 19 |
| Edberg–Lendl | 27 | 1984–1992 | 9 | 5–4 | 14–13 | 1 | 7 |
| Federer–Hewitt | 26 | 1999– | 8 | 8–0 | 18–8 | 1 | 4 |
| Djokovic–Federer | 24 | 2006– | 9 | 4–5 | 10–14 | 1 | 6 |
| Federer–Roddick | 24 | 2001– | 8 | 8–0 | 21–3 | 4 | 7 |
| Borg–Connors | 23 | 1973–1983 | 8 | 5–3 | 15–8 | 4 | 13 |
| Lendl–Wilander | 22 | 1982–1994 | 9 | 5–4 | 15–7 | 5 | 9 |
| Agassi–Chang | 22 | 1988–2003 | 5 | 3–2 | 15–7 | 0 | 4 |
| Borg–Vilas | 22 | 1973–1980 | 3 | 3–0 | 17–5 | 2 | 10 |
| Becker–Lendl | 21 | 1985–1993 | 6 | 5–1 | 10–11 | 3 | 13 |
| Chang–Sampras | 20 | 1989–2001 | 5 | 1–4 | 8–12 | 1 | 3 |
| Edberg–Wilander | 20 | 1983–1995 | 5 | 2–3 | 9–11 | 1 | 5 |
| Courier–Sampras | 20 | 1988–1999 | 8 | 2–6 | 4–16 | 1 | 4 |
| Murray–Nadal | 19 | 2007– | 8 | 2–6 | 5–13 | 0 | 3 |
| Becker–Sampras | 19 | 1990–1997 | 3 | 0–3 | 7–12 | 1 | 7 |
| Ivanisevic–Sampras | 18 | 1990–1999 | 5 | 1–4 | 6–12 | 2 | 4 |
| Rafter–Sampras | 16 | 1993–2001 | 3 | 1–2 | 4–12 | 1 | 5 |
| Federer–Murray | 15 | 2005– | 2 | 2–0 | 7–8 | 2 | 6 |
| Agassi–Rafter | 15 | 1993–2001 | 7 | 4–3 | 10–5 | 0 | 0 |
| Borg–McEnroe | 14 | 1978–1981 | 4 | 1–3 | 7–7 | 4 | 9 |
| Agassi–Becker | 14 | 1988–1999 | 5 | 4–1 | 10–4 | 0 | 1 |
| Djokovic–Murray | 12 | 2006– | 2 | 2–0 | 7–5 | 1 | 4 |
| Federer–Safin | 12 | 2001–2009 | 5 | 4–1 | 10–2 | 1 | 3 |
| Agassi–Courier | 12 | 1989–1996 | 6 | 2–4 | 5–7 | 1 | 2 |